Nucleotide-sugar biosynthetic process

Across TCGA patient cohorts, RNA activity of the Nucleotide-sugar biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FN1, PLOD1, and IKBIP, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleotide-sugar biosynthetic process activity versus FN1 in OV (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	FN1 →	+1.247	+0.041	<.001	.001	3	7
OV	PLOD1 →	+0.574	+0.046	<.001	<.001	3	6
OV	IKBIP →	+0.673	+0.044	<.001	.001	3	6
OV	UAP1L1 →	+0.508	+0.047	<.001	<.001	3	6
OV	CTHRC1 →	+1.307	+0.052	<.001	<.001	3	6
GBM	COL5A1 →	+0.904	+0.051	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009226 vs FN1 — OV

Explore this scatter interactively →