Nucleotide-sugar metabolic process

Across TCGA cell cohorts, RNA activity of the Nucleotide-sugar metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARL4C, FABP1, and LYST, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ARL4C grouped by Nucleotide-sugar metabolic process-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	ARL4C →	-3.531	-1.418	<.001	<.001	3	4
BONE	FABP1 →	+0.412	+1.453	.003	<.001	3	4
BREAST	LYST →	-0.945	-0.964	.002	.001	3	4
SOFT_TISSUE	OSTC →	+0.782	+1.566	.002	<.001	3	4
LUNG_SCLC	SHD →	+2.823	+1.037	<.001	<.001	3	3
LUNG_NSCLC_LUSC	C10orf88 →	-0.828	-1.557	.006	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ARL4C by Nucleotide-sugar metabolic process activity — LIVER

Explore this box plot interactively →