Pyrimidine ribonucleotide catabolic process

Across TCGA patient cohorts, RNA activity of the Pyrimidine ribonucleotide catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MED12_S635, VIRMA, and WDR36, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine ribonucleotide catabolic process activity versus MED12_S635 in COAD (Pearson r = -0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MED12_S635 →	-0.301	-0.051	.001	.001	3	6
BRCA	VIRMA →	-0.240	-0.067	<.001	<.001	3	5
BRCA	WDR36 →	-0.287	-0.051	<.001	<.001	3	5
BRCA	DNTTIP2 →	-0.218	-0.042	<.001	<.001	3	5
COAD	FAM126A →	+0.389	+0.046	.001	.004	3	5
COAD	MCRS1_S282 →	-0.338	-0.043	.008	.008	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009222 vs MED12_S635 — COAD

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