Pyrimidine ribonucleotide catabolic process

Across TCGA patient cohorts, RNA activity of the Pyrimidine ribonucleotide catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NPC2, CLEC7A, and AIF1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine ribonucleotide catabolic process activity versus NPC2 in LUAD (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	NPC2 →	+0.909	+0.218	.002	<.001	3	6
COAD	CLEC7A →	+0.624	+0.187	.008	.002	3	6
LSCC	AIF1 →	+0.697	+0.319	<.001	<.001	3	6
GBM	UPP1 →	+0.921	+0.156	<.001	<.001	3	6
COAD	CD86 →	+0.706	+0.217	<.001	<.001	3	5
LSCC	CYTIP →	+0.439	+0.136	.007	.009	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009222 vs NPC2 — LUAD

Explore this scatter interactively →