Pyrimidine ribonucleotide catabolic process

Across TCGA cell cohorts, RNA activity of the Pyrimidine ribonucleotide catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRIOBP, MAML3, and RNASEL, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine ribonucleotide catabolic process activity versus TRIOBP in OVARY (Pearson r = -0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	TRIOBP →	-1.232	-1.547	.005	.001	3	5
LUNG_NSCLC_LUSC	MAML3 →	-1.722	-1.672	.002	<.001	3	4
URINARY_TRACT	RNASEL →	-1.627	-1.482	.008	<.001	3	4
CNS	RASA1 →	-0.891	-1.035	.002	<.001	3	4
CNS	LAMB1 →	-1.706	-1.142	.003	<.001	3	3
SKIN	KLHL36 →	-0.945	-0.215	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009222 vs TRIOBP — OVARY

Explore this scatter interactively →