Ribonucleoside diphosphate catabolic process

Across TCGA patient cohorts, RNA activity of the Ribonucleoside diphosphate catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ENTPD5, PIGR_S673, and SIN3A, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ribonucleoside diphosphate catabolic process activity versus ENTPD5 in PDAC (Pearson r = 0.01).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	ENTPD5 →	+0.627	+0.058	<.001	<.001	3	7
UCEC	PIGR_S673 →	+1.157	+0.075	.001	.002	3	6
GBM	SIN3A →	-0.214	-0.039	.001	.001	3	6
LSCC	SSB →	-0.416	-0.082	<.001	<.001	3	6
GBM	XRCC5 →	-0.258	-0.066	.002	<.001	3	6
BRCA	GAK →	+0.175	+0.040	.005	.008	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009191 vs ENTPD5 — PDAC

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