Ribonucleoside diphosphate catabolic process

Across TCGA cell cohorts, RNA activity of the Ribonucleoside diphosphate catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SUCLG2, CLCN7, and HMBOX1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SUCLG2 grouped by Ribonucleoside diphosphate catabolic process-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SUCLG2 →	+0.890	+0.343	.001	<.001	3	5
KIDNEY	CLCN7 →	-0.956	-0.174	.003	.006	3	5
STOMACH	HMBOX1 →	-0.667	-0.158	.006	.006	3	5
STOMACH	ZFYVE27 →	-0.801	-0.217	<.001	.001	3	5
BONE	FAM160B2 →	-1.372	-0.367	.001	.002	3	5
URINARY_TRACT	NACA2 →	+0.561	+0.347	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SUCLG2 by Ribonucleoside diphosphate catabolic process activity — SKIN

Explore this box plot interactively →