Cyclic nucleotide metabolic process

Across TCGA patient cohorts, RNA activity of the Cyclic nucleotide metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SYNPO, SYNPO2, and EIF4G1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cyclic nucleotide metabolic process activity versus SYNPO in HNSC (Pearson r = 0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SYNPO →	+0.467	+0.038	<.001	<.001	3	10
CCRCC	SYNPO2 →	+0.779	+0.066	<.001	<.001	3	10
GBM	EIF4G1 →	-0.278	-0.069	<.001	<.001	3	10
UCEC	LMOD1 →	+0.948	+0.047	<.001	<.001	3	10
GBM	SEPTIN4 →	+0.538	+0.043	<.001	<.001	3	9
UCEC	SORBS1 →	+0.739	+0.048	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009187 vs SYNPO — HNSC

Explore this scatter interactively →