Ribonucleoside diphosphate metabolic process

Across TCGA cell cohorts, RNA activity of the Ribonucleoside diphosphate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C10orf95, TNIP1, and HAGH, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, C10orf95 grouped by Ribonucleoside diphosphate metabolic process-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	C10orf95 →	-0.667	-0.458	.009	<.001	3	7
LUNG_SCLC	TNIP1 →	+1.623	+0.232	.002	.001	3	5
SKIN	HAGH →	-0.562	-0.223	.007	.002	3	5
LUNG_NSCLC_LUSC	STON2 →	-3.232	-0.281	.002	.004	3	5
LARGE_INTESTINE	ZNF629 →	-0.699	-0.202	.001	.001	2	5
LARGE_INTESTINE	FBXO28 →	-0.541	-0.172	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

C10orf95 by Ribonucleoside diphosphate metabolic process activity — BLOOD_Lymphoma

Explore this box plot interactively →