Pyrimidine deoxyribonucleoside monophosphate metabolic process

Across TCGA patient cohorts, RNA activity of the Pyrimidine deoxyribonucleoside monophosphate metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MCM2, MCM6, and MCM7, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine deoxyribonucleoside monophosphate metabolic process activity versus MCM2 in LSCC (Pearson r = 0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MCM2 →	+0.554	+0.064	.001	.001	3	8
GBM	MCM6 →	+0.588	+0.058	<.001	<.001	3	8
HNSC	MCM7 →	+0.481	+0.068	<.001	<.001	3	8
LUAD	SHMT1 →	+0.409	+0.051	<.001	<.001	3	7
OV	MCM4 →	+0.684	+0.064	.003	<.001	3	7
GBM	MCM5 →	+0.542	+0.060	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009176 vs MCM2 — LSCC

Explore this scatter interactively →