Pyrimidine deoxyribonucleoside monophosphate metabolic process

Across TCGA cell cohorts, RNA activity of the Pyrimidine deoxyribonucleoside monophosphate metabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TYMS, DUT, and NT5M, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TYMS grouped by Pyrimidine deoxyribonucleoside monophosphate metabolic process-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	TYMS →	-0.912	-0.787	.001	.001	3	11
LARGE_INTESTINE	DUT →	-0.567	-1.213	<.001	.001	3	9
KIDNEY	NT5M →	-0.495	-1.403	<.001	<.001	3	7
BLOOD_Leukemia	SNX27 →	+0.177	+0.904	.001	.003	3	5
BREAST	SLC7A13 →	-0.218	-0.875	.001	.005	3	4
LUNG_SCLC	UPP1 →	-0.244	-1.235	.005	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TYMS by Pyrimidine deoxyribonucleoside monophosphate metabolic process activity — PANCREAS

Explore this box plot interactively →