Pyrimidine ribonucleoside monophosphate biosynthetic process

Across TCGA patient cohorts, RNA activity of the Pyrimidine ribonucleoside monophosphate biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are POC5_S105, LARP1_S151, and DDX21_S71, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine ribonucleoside monophosphate biosynthetic process activity versus POC5_S105 in BRCA (Pearson r = -0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	POC5_S105 →	-0.470	-0.035	.005	.008	3	6
PDAC	LARP1_S151 →	-0.410	-0.051	.004	<.001	3	4
BRCA	DDX21_S71 →	+0.725	+0.028	.001	<.001	3	4
GBM	KDM2A_S692 →	+0.314	+0.034	.003	.005	3	4
BRCA	UBE2M_S28 →	-0.917	-0.027	.008	.006	3	4
UCEC	AGR3 →	-0.895	-0.057	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009174 vs POC5_S105 — BRCA

Explore this scatter interactively →