Pyrimidine ribonucleoside monophosphate biosynthetic process

Across TCGA patient cohorts, RNA activity of the Pyrimidine ribonucleoside monophosphate biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KIF18A, HASPIN, and CENPO, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine ribonucleoside monophosphate biosynthetic process activity versus KIF18A in LUAD (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	KIF18A →	+0.564	+0.164	.002	.005	3	4
LUAD	HASPIN →	+0.392	+0.135	.007	.002	3	4
LSCC	CENPO →	+0.448	+0.144	.004	.001	3	4
HNSC	DCBLD2 →	+0.734	+0.162	.004	.006	3	4
CCRCC	COPS8P2 →	-0.266	-0.160	.009	.002	3	3
LUAD	ADCY3 →	+0.396	+0.163	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009174 vs KIF18A — LUAD

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