Q-omics provides the consensus-scored COPS8P2 profile across patient tissues and cancer cell-line models. COPS8P2 expression is associated with patient survival in 24 of 34 cancer types, with the highest sampling consensus in UVM. Among the 18 cancer types available for tumor–normal comparison, COPS8P2 is differentially expressed in 8, with the highest sampling consensus in COAD. Additionally, COPS8P2 RNA expression shows 14,245 significant protein co-abundance associations, with the highest sampling consensus in GBM. Together, these results highlight UVM, COAD, and GBM as cancer lineages where COPS8P2 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for COPS8P2 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes COPS8P2 survival associations across molecular data types. COPS8P2 RNA expression shows survival associations in the most cancer types (24). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible COPS8P2 RNA expression–survival associations across cancer types. High COPS8P2 expression shows unfavorable associations in UVM, MESO, OV and DLBC, but favorable associations in COAD and PRAD. The UVM Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify UVM as the clearest survival context for COPS8P2 RNA expression.
This table summarizes COPS8P2 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 8. The strongest signals are observed in COAD for RNA.
This table ranks reproducible tumor–normal expression differences for COPS8P2. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. COPS8P2 shows lower tumor expression in PAAD and ESCA and higher tumor expression in COAD, HNSC, BRCA and LUAD. The COAD box plot shows higher COPS8P2 RNA expression in tumor versus normal tissue (log2 FC = +0.383, t-test p < 0.001).
This table shows molecular features associated with COPS8P2 in patient tissues and cancer cell lines. In patient samples, COPS8P2 shows the broadest associations at the RNA and protein expression levels, with GBM recurring as the lineage with the largest associated feature set.
