Purine deoxyribonucleoside monophosphate metabolic process

Across TCGA patient cohorts, RNA activity of the Purine deoxyribonucleoside monophosphate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZBED2, LCP2, and IL21R, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Purine deoxyribonucleoside monophosphate metabolic process activity versus ZBED2 in UCEC (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZBED2 →	+0.885	+0.159	.002	.001	3	5
GBM	LCP2 →	+0.771	+0.135	<.001	.001	3	5
GBM	IL21R →	+0.889	+0.121	<.001	.005	3	4
LUAD	PTPN7 →	+0.536	+0.180	.002	.006	3	4
GBM	ARHGAP27 →	+0.414	+0.113	.003	.009	3	4
BRCA	UBASH3A →	+0.539	+0.110	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009170 vs ZBED2 — UCEC

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