Purine deoxyribonucleoside monophosphate metabolic process

Across TCGA pan-cancer cohorts, RNA activity of the Purine deoxyribonucleoside monophosphate metabolic process pathway is associated with patient survival in 22 of 34 cancer lineages. Pathway activity is summarized from the expression of its 10 member genes.

The strongest signal is observed in small cell lung cancer (SCLC), where higher Purine deoxyribonucleoside monophosphate metabolic process pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as ESCA and THYM, show the opposite pattern, with higher activity associated with better survival.

SCLC, UCEC, and UVM are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	DFS	Median	All	0.488	0.734	<.001	109	view →
UCEC	DFS	Tertile	All	0.503	0.718	<.001	108	view →
UVM	DFS	Tertile	II,III,IV	0.310	0.733	<.001	107	view →
KIRP	OS	Median	All	0.457	0.818	<.001	43	view →
STAD	OS	Tertile	III,IV	0.270	0.667	<.001	43	view →
BLCA	DFS	Quartile	All	0.268	0.524	.002	39	view →
ESCA	OS	Quartile	III,IV	0.870	0.299	.004	24	view →
PCPG	DFS	Tertile	All	0.350	0.882	.003	21	view →
THYM	OS	Median	II,III,IV	1.000	0.885	.008	18	view →
THCA	DFS	Quartile	IV	0.509	0.996	.007	18	view →
OV	OS	Median	III,IV	0.791	0.866	.004	18	view →
KIRC	OS	Tertile	All	0.541	0.706	.004	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

GO:0009170–SCLC (DFS)

Open the SCLC breakdown →