Ribonucleoside monophosphate metabolic process

pathway activity — cross-omics
GO:0009161Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Ribonucleoside monophosphate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC2A1, SLC2A5, and PELATON, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
PDACSLC2A1 →+0.829+0.110.003.00235
OVSLC2A5 →+0.801+0.141.002.00935
COADPELATON →+0.447+0.205<.001<.00135
COADFCGR2B →+0.976+0.252<.001<.00135
BRCAPRKAB1 →-0.331-0.140<.001<.00134
BRCASRGN →+0.694+0.124<.001.00134
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration