Deoxyribonucleoside monophosphate catabolic process

Across TCGA patient cohorts, RNA activity of the Deoxyribonucleoside monophosphate catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the ACC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAC2, TYMP, and UPP1, each associated with the pathway in up to 28 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Deoxyribonucleoside monophosphate catabolic process activity versus RAC2 in ACC (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ACC	RAC2 →	+2.531	+0.070	<.001	.001	3	28
BLCA	TYMP →	+1.872	+0.085	<.001	<.001	3	27
TGCT	UPP1 →	+1.990	+0.067	<.001	<.001	3	25
LAML	HK3 →	+1.550	+0.045	<.001	<.001	3	25
SCLC	ISG15 →	+1.497	+0.170	<.001	<.001	3	25
BLCA	ADA →	+1.382	+0.086	<.001	<.001	3	25

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009159 vs RAC2 — ACC

Explore this scatter interactively →