Ribonucleoside monophosphate catabolic process

Across TCGA patient cohorts, RNA activity of the Ribonucleoside monophosphate catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SLC2A5, EIF5B_S137, and SRRM2_S2123, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ribonucleoside monophosphate catabolic process activity versus SLC2A5 in OV (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SLC2A5 →	+0.859	+0.177	<.001	<.001	3	5
COAD	EIF5B_S137 →	-1.169	-0.229	.001	<.001	3	4
UCEC	SRRM2_S2123 →	-0.334	-0.195	<.001	<.001	3	4
BRCA	UPP1 →	+0.674	+0.221	<.001	<.001	3	4
UCEC	ZC3H13_S198 →	-0.518	-0.142	<.001	<.001	3	4
OV	USP39_S46 →	-0.847	-0.193	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009158 vs SLC2A5 — OV

Explore this scatter interactively →