Ribonucleoside monophosphate biosynthetic process

Across TCGA cell cohorts, RNA activity of the Ribonucleoside monophosphate biosynthetic process pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCND1, POR, and PIGG, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CCND1 grouped by Ribonucleoside monophosphate biosynthetic process-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CCND1 →	-0.451	-0.059	.005	.004	2	6
BLOOD_Myeloma	POR →	+0.305	+0.088	.002	.003	3	4
BONE	PIGG →	-0.353	-0.100	.001	.001	3	4
SKIN	NLRP12 →	+0.192	+0.062	.004	.002	2	5
LUNG_SCLC	PAIP1 →	+0.186	+0.115	.005	.006	3	4
LUNG_SCLC	ARIH2 →	-0.188	-0.088	.003	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CCND1 by Ribonucleoside monophosphate biosynthetic process activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →