Purine deoxyribonucleotide catabolic process

Across TCGA cell cohorts, RNA activity of the Purine deoxyribonucleotide catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TLK1, PPP4R3B, and ADA, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Purine deoxyribonucleotide catabolic process activity versus TLK1 in UPPER_AERODIGESTIVE_TRACT (Pearson r = -0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	TLK1 →	-0.691	-0.092	.001	.001	3	10
BONE	PPP4R3B →	-0.575	-0.167	<.001	<.001	3	8
BLOOD_Lymphoma	ADA →	+2.239	+0.073	<.001	<.001	3	8
BREAST	TBC1D15 →	-0.608	-0.081	.005	.004	2	8
BONE	ELMOD2 →	-0.753	-0.115	.002	.004	3	7
BONE	MARCHF6 →	-0.884	-0.134	.001	.004	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009155 vs TLK1 — UPPER_AERODIGESTIVE_TRACT

Explore this scatter interactively →