Nucleoside triphosphate catabolic process

Across TCGA cell cohorts, RNA activity of the Nucleoside triphosphate catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UCK2, TTLL12, and MDH2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleoside triphosphate catabolic process activity versus UCK2 in OVARY (Pearson r = 0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	UCK2 →	+1.159	+1.125	.001	.006	3	6
BLOOD_Myeloma	TTLL12 →	+0.781	+0.301	.002	.002	3	6
STOMACH	MDH2 →	+0.685	+0.778	<.001	.008	3	6
BLOOD_Leukemia	LSM4 →	+0.616	+0.189	<.001	.001	3	5
OVARY	C12orf45 →	+1.169	+1.381	<.001	<.001	3	5
OVARY	MBOAT1 →	-1.438	-0.791	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009143 vs UCK2 — OVARY

Explore this scatter interactively →