Nucleoside triphosphate metabolic process

Across TCGA cell cohorts, RNA activity of the Nucleoside triphosphate metabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP5PO, ATP5F1B, and COX7C, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ATP5PO grouped by Nucleoside triphosphate metabolic process-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ATP5PO →	-0.327	-0.191	<.001	<.001	3	9
URINARY_TRACT	ATP5F1B →	-0.442	-0.412	<.001	.001	3	7
PANCREAS	COX7C →	-0.216	-0.167	.004	.008	3	7
LUNG_SCLC	NDUFB5 →	-0.262	-0.290	.005	<.001	2	8
LUNG_NSCLC_LUSC	ATP5PD →	-0.379	-0.235	.002	.001	3	7
BREAST	HCCS →	-0.374	-0.209	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ATP5PO by Nucleoside triphosphate metabolic process activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →