Nucleoside triphosphate metabolic process

Across TCGA cell cohorts, RNA activity of the Nucleoside triphosphate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MCRIP2, DNAJA3, and RAB40C, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleoside triphosphate metabolic process activity versus MCRIP2 in BLOOD_Leukemia (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MCRIP2 →	+1.432	+0.156	<.001	<.001	2	6
LUNG_NSCLC_LUAD	DNAJA3 →	+0.610	+0.164	.002	.008	3	5
LUNG_SCLC	RAB40C →	+0.792	+0.195	.001	.002	3	5
LUNG_SCLC	MRPS33 →	+0.894	+0.172	<.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	SUCLG1 →	+0.808	+0.255	.002	.006	3	5
STOMACH	COQ9 →	+0.825	+0.193	.005	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009141 vs MCRIP2 — BLOOD_Leukemia

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