Purine nucleoside diphosphate biosynthetic process

Across TCGA patient cohorts, RNA activity of the Purine nucleoside diphosphate biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AK4, C19orf73, and RGS7BP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Purine nucleoside diphosphate biosynthetic process activity versus AK4 in LSCC (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	AK4 →	+1.211	+0.152	<.001	<.001	3	5
LSCC	C19orf73 →	+0.508	+0.106	.001	.004	3	4
GBM	RGS7BP →	+1.200	+0.178	<.001	.001	3	4
HNSC	RIMS3 →	+0.908	+0.138	.005	.004	3	4
GBM	ELOVL4 →	+0.578	+0.138	<.001	.001	3	4
GBM	IPCEF1 →	+0.708	+0.143	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009136 vs AK4 — LSCC

Explore this scatter interactively →