Purine nucleoside diphosphate metabolic process

Across TCGA cell cohorts, RNA activity of the Purine nucleoside diphosphate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LRP10, RPL5, and BTN2A2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LRP10 grouped by Purine nucleoside diphosphate metabolic process-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	LRP10 →	-1.276	-0.296	.002	<.001	3	5
PANCREAS	RPL5 →	+0.692	+0.250	<.001	<.001	3	5
PANCREAS	BTN2A2 →	+0.922	+0.244	.004	<.001	3	5
LUNG_SCLC	C8orf82 →	-1.436	-0.226	<.001	.002	3	5
LUNG_SCLC	ATP2A3 →	-3.528	-0.321	<.001	<.001	3	5
BREAST	HOMEZ →	-0.742	-0.406	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LRP10 by Purine nucleoside diphosphate metabolic process activity — PANCREAS

Explore this box plot interactively →