Pyrimidine nucleoside monophosphate catabolic process

Across TCGA cell cohorts, RNA activity of the Pyrimidine nucleoside monophosphate catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CHD8, SH2B3, and SMG1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CHD8 grouped by Pyrimidine nucleoside monophosphate catabolic process-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	CHD8 →	+0.558	+1.847	<.001	<.001	3	5
CNS	SH2B3 →	+1.952	+1.277	.006	<.001	3	5
KIDNEY	SMG1 →	+1.431	+1.373	<.001	<.001	3	5
LUNG_NSCLC_LUAD	EIF4EBP1 →	+0.893	+0.856	<.001	.001	3	5
LIVER	PRR11 →	+1.143	+1.551	.002	.002	3	5
KIDNEY	GTF2A1 →	+0.690	+0.991	.005	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CHD8 by Pyrimidine nucleoside monophosphate catabolic process activity — LIVER

Explore this box plot interactively →