Pyrimidine nucleoside monophosphate biosynthetic process

Across TCGA cell cohorts, RNA activity of the Pyrimidine nucleoside monophosphate biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FA2H, SGPP2, and ANTXR1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FA2H grouped by Pyrimidine nucleoside monophosphate biosynthetic process-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	FA2H →	+2.386	+0.511	.004	.003	3	5
STOMACH	SGPP2 →	+2.334	+0.362	<.001	.003	3	5
LIVER	ANTXR1 →	-3.653	-0.376	<.001	.001	3	5
LIVER	NDST1 →	-1.526	-0.404	.009	.002	3	5
STOMACH	PTK6 →	+2.710	+0.346	<.001	.005	3	4
STOMACH	SDCBP2 →	+2.993	+0.346	<.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FA2H by Pyrimidine nucleoside monophosphate biosynthetic process activity — STOMACH

Explore this box plot interactively →