Pyrimidine nucleoside monophosphate metabolic process

Across TCGA patient cohorts, RNA activity of the Pyrimidine nucleoside monophosphate metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MCM4, MCM7, and WDHD1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine nucleoside monophosphate metabolic process activity versus MCM4 in LUAD (Pearson r = 0.55).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MCM4 →	+0.514	+0.037	.001	.004	3	7
LUAD	MCM7 →	+0.466	+0.046	.008	.002	3	7
GBM	WDHD1 →	+0.539	+0.049	<.001	<.001	3	6
LSCC	WDHD1_S383 →	+0.755	+0.058	<.001	<.001	3	6
LSCC	DLGAP5 →	+0.609	+0.066	<.001	<.001	3	6
GBM	NDC80 →	+0.603	+0.052	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009129 vs MCM4 — LUAD

Explore this scatter interactively →