Pyrimidine nucleoside monophosphate metabolic process

Across TCGA cell cohorts, RNA activity of the Pyrimidine nucleoside monophosphate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TLE2, TUT4, and ZKSCAN2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine nucleoside monophosphate metabolic process activity versus TLE2 in BONE (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	TLE2 →	+3.136	+0.438	.002	.001	2	6
BLOOD_Leukemia	TUT4 →	+0.538	+0.251	.003	.008	3	5
BLOOD_Leukemia	ZKSCAN2 →	+0.434	+0.281	.005	.003	3	5
BLOOD_Leukemia	LEAP2 →	+0.845	+0.187	<.001	.001	3	5
BLOOD_Leukemia	MCM7 →	+0.561	+0.185	.003	<.001	3	5
BLOOD_Leukemia	EWSR1 →	+0.487	+0.248	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009129 vs TLE2 — BONE

Explore this scatter interactively →