Purine nucleoside monophosphate biosynthetic process

Across TCGA patient cohorts, RNA activity of the Purine nucleoside monophosphate biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ADA, CAPZA1, and FMO5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Purine nucleoside monophosphate biosynthetic process activity versus ADA in UCEC (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ADA →	+0.523	+0.184	<.001	<.001	2	5
UCEC	CAPZA1 →	+0.275	+0.182	<.001	<.001	3	4
COAD	FMO5 →	-0.659	-0.243	<.001	<.001	3	3
COAD	GAB3_S344 →	+0.470	+0.270	.003	.001	3	3
PDAC	PLEC_S1047 →	+1.298	+0.143	.001	<.001	3	3
PDAC	PLEC_S896 →	+1.298	+0.143	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009127 vs ADA — UCEC

Explore this scatter interactively →