Purine nucleoside monophosphate biosynthetic process

Across TCGA cell cohorts, RNA activity of the Purine nucleoside monophosphate biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PAICS, PPAT, and DNA2, each associated with the pathway in up to 19 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Purine nucleoside monophosphate biosynthetic process activity versus PAICS in PANCREAS (Pearson r = 0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	PAICS →	+1.405	+0.175	<.001	<.001	3	19
PANCREAS	PPAT →	+1.235	+0.169	<.001	<.001	3	18
BLOOD_Lymphoma	DNA2 →	+1.125	+0.120	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	MRPS27 →	+1.034	+0.110	.002	<.001	3	16
BLOOD_Lymphoma	SRSF7 →	+1.080	+0.137	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	HEATR1 →	+1.137	+0.110	.001	.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009127 vs PAICS — PANCREAS

Explore this scatter interactively →