Purine nucleoside monophosphate metabolic process

Across TCGA patient cohorts, RNA activity of the Purine nucleoside monophosphate metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are UPP1, C1QB, and PLAU, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Purine nucleoside monophosphate metabolic process activity versus UPP1 in LUAD (Pearson r = 0.42).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	UPP1 →	+0.541	+0.029	<.001	<.001	3	6
GBM	C1QB →	+0.512	+0.052	<.001	<.001	3	6
CCRCC	PLAU →	+1.056	+0.053	<.001	<.001	3	6
CCRCC	PLTP →	+0.765	+0.037	.001	.002	3	6
GBM	HCK →	+0.641	+0.053	<.001	<.001	3	6
BRCA	ITGAM →	+0.528	+0.035	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009126 vs UPP1 — LUAD

Explore this scatter interactively →