Nucleoside monophosphate biosynthetic process

Across TCGA patient cohorts, RNA activity of the Nucleoside monophosphate biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TIGIT, IGHV3-30, and IL12RB2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleoside monophosphate biosynthetic process activity versus TIGIT in UCEC (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TIGIT →	+0.600	+0.162	.007	.001	3	4
UCEC	IGHV3-30 →	+2.248	+0.192	.002	<.001	3	4
BRCA	IL12RB2 →	+0.660	+0.167	.002	<.001	3	4
LSCC	SNORA31 →	-0.573	-0.138	<.001	<.001	3	4
BRCA	TFEC →	+0.668	+0.161	<.001	<.001	3	4
LUAD	SIRPG →	+0.582	+0.140	.007	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009124 vs TIGIT — UCEC

Explore this scatter interactively →