Nucleoside monophosphate metabolic process

Across TCGA cell cohorts, RNA activity of the Nucleoside monophosphate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MUC1, TM4SF5, and SLC5A3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MUC1 grouped by Nucleoside monophosphate metabolic process-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	MUC1 →	+3.997	+0.421	<.001	.001	3	5
LIVER	TM4SF5 →	+4.648	+0.167	.002	.004	3	4
LIVER	SLC5A3 →	-1.295	-0.159	.002	.007	3	4
STOMACH	CAPN8 →	+4.316	+0.316	<.001	.001	3	4
BLOOD_Myeloma	CAVIN4 →	-0.982	-0.352	.002	.004	3	4
KIDNEY	THAP1 →	-0.487	-0.191	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MUC1 by Nucleoside monophosphate metabolic process activity — STOMACH

Explore this box plot interactively →