Deoxyribonucleoside metabolic process

Across TCGA patient cohorts, RNA activity of the Deoxyribonucleoside metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ILF2, AHNAK_S5448, and LPXN, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Deoxyribonucleoside metabolic process activity versus ILF2 in OV (Pearson r = -0.45).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ILF2 →	-0.274	-0.054	.003	<.001	3	6
LSCC	AHNAK_S5448 →	+0.471	+0.056	.009	.001	3	5
OV	LPXN →	+0.685	+0.055	<.001	<.001	3	5
OV	SIPA1 →	+0.239	+0.044	.002	<.001	3	5
OV	SNX29 →	+0.399	+0.037	.009	.004	3	5
UCEC	PLEKHO2 →	+0.409	+0.089	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009120 vs ILF2 — OV

Explore this scatter interactively →