Deoxyribonucleoside metabolic process

Across TCGA pan-cancer cohorts, RNA activity of the Deoxyribonucleoside metabolic process pathway is associated with patient survival in 24 of 34 cancer lineages. Pathway activity is summarized from the expression of its 11 member genes.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher Deoxyribonucleoside metabolic process pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as SKCM and ESCA, show the opposite pattern, with higher activity associated with better survival.

UCEC, SKCM, and ESCA are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Tertile	II,III,IV	0.778	0.934	<.001	100	view →
SKCM	OS	Median	All	0.422	0.252	<.001	58	view →
ESCA	DFS	Quartile	III,IV	0.703	0.222	<.001	55	view →
LGG	OS	Median	All	0.753	0.866	<.001	47	view →
KICH	OS	Median	All	0.749	0.972	.006	42	view →
UVM	OS	Median	III,IV	0.391	0.875	.003	30	view →
KIRP	DFS	Quartile	All	0.517	0.917	.001	29	view →
PAAD	OS	Tertile	All	0.217	0.501	.004	29	view →
CHOL	DFS	Median	IV	0.082	0.753	.008	21	view →
BLCA	DFS	Quartile	All	0.426	0.558	.014	16	view →
STAD	OS	Tertile	III,IV	0.310	0.594	.002	12	view →
SCLC	DFS	Median	II,III,IV	0.427	0.984	.009	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

GO:0009120–UCEC (OS)

Open the UCEC breakdown →