Deoxyribonucleoside metabolic process

Across TCGA patient cohorts, RNA activity of the Deoxyribonucleoside metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EGFR, BBS10, and TPBG, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Deoxyribonucleoside metabolic process activity versus EGFR in LUAD (Pearson r = 0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	EGFR →	+1.061	+0.212	.005	.003	3	5
LSCC	BBS10 →	-0.545	-0.119	<.001	.001	3	5
LUAD	TPBG →	+0.531	+0.191	.004	.001	3	5
BRCA	UHMK1 →	-0.906	-0.110	<.001	.003	3	5
LSCC	NAA25 →	-0.328	-0.107	.001	<.001	3	5
LSCC	DENR →	-0.551	-0.155	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009120 vs EGFR — LUAD

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