Deoxyribonucleoside metabolic process

Across TCGA cell cohorts, RNA activity of the Deoxyribonucleoside metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLUH, YJU2, and CHAF1A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CLUH grouped by Deoxyribonucleoside metabolic process-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CLUH →	-0.498	-0.580	.001	.001	3	5
LUNG_SCLC	YJU2 →	-0.692	-1.109	.009	.007	3	4
KIDNEY	CHAF1A →	-1.002	-1.304	.001	.001	3	4
SOFT_TISSUE	APOL3 →	+1.516	+1.308	.002	<.001	3	4
LUNG_NSCLC_LUAD	CMC4 →	+0.818	+0.765	.007	.003	2	5
LUNG_NSCLC_LUAD	PNP →	-0.741	-0.801	.009	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CLUH by Deoxyribonucleoside metabolic process activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →