Deoxyribonucleoside metabolic process

Across TCGA cell cohorts, RNA activity of the Deoxyribonucleoside metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POLR1B, AAMP, and DNAJC7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Deoxyribonucleoside metabolic process activity versus POLR1B in PANCREAS (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	POLR1B →	+0.879	+0.481	<.001	<.001	3	4
PANCREAS	AAMP →	+0.481	+0.566	.008	.002	3	4
LIVER	DNAJC7 →	+0.585	+0.499	.007	<.001	3	4
BLOOD_Lymphoma	DPH3 →	-0.777	-0.136	.001	.009	2	5
BLOOD_Lymphoma	ADK →	-0.955	-0.195	.001	.005	3	4
LIVER	PSME3 →	+0.590	+0.472	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009120 vs POLR1B — PANCREAS

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