Glutamine family amino acid biosynthetic process

Across TCGA patient cohorts, RNA activity of the Glutamine family amino acid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GIMAP4, GBP4, and GIMAP7, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glutamine family amino acid biosynthetic process activity versus GIMAP4 in CCRCC (Pearson r = -0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	GIMAP4 →	-0.438	-0.240	.003	<.001	3	4
CCRCC	GBP4 →	-0.689	-0.176	<.001	.003	3	4
LSCC	GIMAP7 →	-0.606	-0.141	.001	.007	3	4
LUAD	TRBV7-4 →	-0.469	-0.145	<.001	.002	3	4
LSCC	PPP1R16B →	-0.660	-0.151	.002	.002	3	4
LSCC	PLCB2 →	-0.427	-0.129	.004	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009084 vs GIMAP4 — CCRCC

Explore this scatter interactively →