Glutamine family amino acid biosynthetic process

Across TCGA pan-cancer cohorts, RNA activity of the Glutamine family amino acid biosynthetic process pathway differs between tumor and matched normal tissue in 17 of the 18 cancer types tested.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where pathway activity is higher in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as KICH and THCA, show the opposite pattern, with lower activity in tumor tissue.

BLCA, LUSC, and LUAD show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
BLCA	Female	III,IV	+0.095	<.001	12	view →
LUSC	Male	III,IV	+0.137	<.001	8	view →
LUAD	Female	III,IV	+0.127	<.001	8	view →
STAD	All	II,III,IV	+0.088	<.001	8	view →
LIHC	Male	II,III,IV	+0.062	<.001	8	view →
COAD	Male	All	+0.057	<.001	8	view →
HNSC	Male	All	+0.047	<.001	7	view →
BRCA	All	All	+0.059	<.001	6	view →
READ	All	All	+0.072	<.001	5	view →
CHOL	All	All	+0.089	<.001	3	view →
KIRC	All	III,IV	+0.027	.013	3	view →
UCEC	All	All	+0.064	<.001	2	view →

Pink = more active in tumor, green = less active in tumor. Showing the 12 strongest of 17 lineages.

GO:0009084–BLCA

Open the BLCA breakdown →