Glutamine family amino acid biosynthetic process

Across TCGA cell cohorts, RNA activity of the Glutamine family amino acid biosynthetic process pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ASS1, PYCR2, and NAGS, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ASS1 grouped by Glutamine family amino acid biosynthetic process-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ASS1 →	-0.316	-1.105	<.001	.001	3	4
UPPER_AERODIGESTIVE_TRACT	PYCR2 →	-0.191	-0.363	.001	.002	3	4
UPPER_AERODIGESTIVE_TRACT	NAGS →	-0.368	-0.507	.002	.002	3	4
BREAST	FANCL →	-0.177	-0.894	.007	.001	3	4
BONE	ASL →	-0.276	-0.316	.001	.001	2	4
OVARY	SULT6B1 →	-0.217	-1.302	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ASS1 by Glutamine family amino acid biosynthetic process activity — OVARY

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