Glutamine family amino acid biosynthetic process

Across TCGA cell cohorts, RNA activity of the Glutamine family amino acid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SIX2, KLRG1, and TMEM267, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SIX2 grouped by Glutamine family amino acid biosynthetic process-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SIX2 →	+1.344	+0.905	.002	.008	3	4
LUNG_SCLC	KLRG1 →	+1.368	+1.215	<.001	.001	3	4
CNS	TMEM267 →	+0.437	+0.856	<.001	<.001	3	3
SKIN	NEIL2 →	+0.584	+0.649	<.001	.005	3	3
SKIN	DPY19L4 →	+0.466	+0.877	.002	.001	3	3
SKIN	ZNF624 →	+0.377	+1.072	.009	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SIX2 by Glutamine family amino acid biosynthetic process activity — OESOPHAGUS

Explore this box plot interactively →