Glutamine family amino acid biosynthetic process

Across TCGA cell cohorts, RNA activity of the Glutamine family amino acid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BTBD6, FAXC, and ZNF629, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glutamine family amino acid biosynthetic process activity versus BTBD6 in LUNG_SCLC (Pearson r = -0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	BTBD6 →	-0.820	-0.270	.005	.002	3	5
LIVER	FAXC →	+1.752	+0.262	<.001	.001	3	5
SKIN	ZNF629 →	-0.940	-0.217	.003	.007	3	5
URINARY_TRACT	C15orf40 →	-0.560	-0.405	.006	<.001	3	4
SOFT_TISSUE	HPS4 →	-0.484	-0.238	.005	.001	3	4
CNS	MRPL38 →	+0.376	+0.186	.007	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009084 vs BTBD6 — LUNG_SCLC

Explore this scatter interactively →