Serine family amino acid biosynthetic process

Across TCGA patient cohorts, RNA activity of the Serine family amino acid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HIBADH, IGFBP6, and RAB7B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Serine family amino acid biosynthetic process activity versus HIBADH in CCRCC (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	HIBADH →	+0.474	+0.118	<.001	<.001	3	4
CCRCC	IGFBP6 →	-0.651	-0.151	.005	<.001	3	4
CCRCC	RAB7B →	-0.564	-0.125	.004	.002	3	4
CCRCC	FAR2 →	-0.341	-0.126	.003	.006	3	4
COAD	GPR68 →	-0.654	-0.199	<.001	<.001	3	3
COAD	ZDHHC4 →	+0.244	+0.108	.002	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009070 vs HIBADH — CCRCC

Explore this scatter interactively →