Serine family amino acid biosynthetic process

Across TCGA cell cohorts, RNA activity of the Serine family amino acid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PHGDH, SNRPA, and TMEM135, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Serine family amino acid biosynthetic process activity versus PHGDH in BLOOD_Lymphoma (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	PHGDH →	+3.232	+0.250	.009	.004	3	9
BLOOD_Lymphoma	SNRPA →	+0.487	+0.241	.002	<.001	3	6
BONE	TMEM135 →	+1.602	+0.253	.001	.008	3	6
BONE	CLTB →	-1.645	-0.312	<.001	<.001	3	6
BREAST	KHDRBS1 →	+0.602	+0.222	.002	.004	3	6
BLOOD_Leukemia	CCDC138 →	+0.897	+0.266	.004	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009070 vs PHGDH — BLOOD_Lymphoma

Explore this scatter interactively →