Aerobic respiration

Across TCGA patient cohorts, RNA activity of the Aerobic respiration pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LGALS1, PRMT9, and IKBIP, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Aerobic respiration activity versus LGALS1 in UCEC (Pearson r = -0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LGALS1 →	-0.957	-0.159	.001	.001	3	6
LUAD	PRMT9 →	-0.322	-0.160	.001	.001	3	5
UCEC	IKBIP →	-0.532	-0.254	<.001	<.001	3	5
BRCA	UPP1 →	-0.653	-0.244	<.001	<.001	3	5
UCEC	C1orf54 →	-0.895	-0.180	.003	.003	3	5
UCEC	ZNF143 →	-0.396	-0.156	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009060 vs LGALS1 — UCEC

Explore this scatter interactively →