"Pentose-phosphate shunt, non-oxidative branch"

Across TCGA patient cohorts, RNA activity of the "Pentose-phosphate shunt, non-oxidative branch" pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are THOC7, F3, and HECTD3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Pentose-phosphate shunt, non-oxidative branch" activity versus THOC7 in GBM (Pearson r = 0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	THOC7 →	+0.226	+0.046	.003	<.001	3	7
COAD	F3 →	-0.793	-0.029	.001	.001	2	6
LSCC	HECTD3 →	-0.156	-0.053	.003	.001	2	6
GBM	ANKFY1 →	-0.223	-0.050	<.001	<.001	3	5
GBM	KDM1A →	+0.260	+0.040	.003	.004	3	5
PDAC	RAB31 →	-0.433	-0.040	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009052 vs THOC7 — GBM

Explore this scatter interactively →