"Pentose-phosphate shunt, non-oxidative branch"

Across TCGA cell cohorts, RNA activity of the "Pentose-phosphate shunt, non-oxidative branch" pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GGACT, PPP3CC, and NFIL3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GGACT grouped by "Pentose-phosphate shunt, non-oxidative branch"-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	GGACT →	+1.096	+2.005	.009	<.001	2	5
PANCREAS	PPP3CC →	-0.923	-1.373	.009	.004	3	4
LUNG_NSCLC_LUSC	NFIL3 →	-1.261	-1.170	.002	.005	3	4
BLOOD_Myeloma	EYA3 →	-0.894	-1.446	.001	.003	3	4
BONE	PIH1D2 →	-0.403	-1.485	.006	.002	2	4
BONE	TAS1R3 →	+0.398	+1.734	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GGACT by "Pentose-phosphate shunt, non-oxidative branch" activity — BLOOD_Lymphoma

Explore this box plot interactively →